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Binding of dominant coronavirus strain to host cell

  • Posted By
    10Pointer
  • Categories
    Science & Technology
  • Published
    20th Apr, 2021

Large-scale supercomputer simulations at the atomic level showed that the dominant ‘G form’ variant of the Covid-19-causing virus is more infectious because of its greater ability to readily bind to host receptor in the body in comparison to other variants.

Context

Large-scale supercomputer simulations at the atomic level showed that the dominant ‘G form’ variant of the Covid-19-causing virus is more infectious because of its greater ability to readily bind to host receptor in the body in comparison to other variants.

What is G Variant?

  • The G variant is also known as D614G is a variant of Covid-19 and is more infectious.
  • Current vaccines for SARS-CoV-2 are basically based on the original D614 form of the virus.
  • The dominant ‘G’ form of SARS-CoV-2 was mutated to a conformation which attaches to its host receptor more easily.
  • Los Alamos National Laboratory of the US Department of Energy discovered the D614G variant in early 2020.
  • Study: This new study of the G variant could offer a backbone for future vaccines.
  • It also makes it more susceptible to antibodies than the original ‘D’ form.

About the Study

  • The interactions among the building blocks of the spike are more symmetrical in the G variant than those in the original D strain.
  • The results shows that the symmetry of interaction make the antibodies to neutralize them easily.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Verifying, please be patient.

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